True to the base theme, yep. Situations where no matter what players do, they cannot change a course of events, never never never, in spite of the fact that the characters are creatures that could, conceivably, change events, that's not cool.
eg, I am running something set in San Francisco in 1906. The PCs cannot stop the earthquake from happening, because they are humans with the powers of humans in 1906 and it's just an earthquake, they can't even predict it. Okay. Same setting, but now I say that the earthquake is caused by the Eldrich Powers the PCs are fighting. They are superheroes, and can fight Eldrich Powers. I can set them up so that really, stopping the EPs is beyond them, but it is not okay for me to say hard-stop never-never-never.