MOAR INFO! From an interview with Dawkins and Karim, two of the devs/writers.
Karim told a bit about their goal for the corebook, where they want to bring being a vampire back into focus.
Political and Personal Horror are brought into the spotlight, as they seem especially relevant today.
An explanation about Generation came up and it's pretty darn smart.
Besides being a measurement of your steps from the progenitor of all vampires, Generation is seemingly going to be the capstone of Blood Potency of the individual vampire.
(With 11th Gen for instance capping it out on 3.)
And there apparently also is a BP mechanic apparently also have a mechanic to interact with the Rouse system, granting re-rolls when invoking Disciplines.
Bane Severity is tied to Blood Potency, and Bane Severity also judges how bad sunlight hurts you.
Karim also spoke to great lengths about Humanity, and how each Troupe needs to tailor their own version Sins. (This is sure to piss off the people who wants a unified mechanic to simulate the world.) and how you can play a Vampire without Touchstones. So, Elders are clearly working on a very different scale of Humanity.
In regards to Paths of Enlightenment, they spoke of making Touchstones out of different things, maybe even making your Pack Priest a Touchstone. But, there's quite the way until that happens.
There was also talked about the Conflict system, and how the system can be varied in detail, with certain conflicts just being able to be settled by simple difficulty, which was also the reason for the new dice system, where you can just half the dice pool to make a difficulty, and always decide not to roll under certain conditions, avoiding the use of the Hunger Dice.
Willpower was re-iterated as being extremely important, and the Compulsion lists were cited as being an optional rule, and more suggestions than actual rules.
They also spoke a great deal about Loresheets, and how they are used to tie the player to the setting and the meta-plot.
The Dream of Byzantium is supposed to be a Loresheet. I'm unsure if I like it being scaled as a Background instead of Merits, as I really don't want every Toreador to have a few dots in Loresheet: Helena, because they wanted one of the things, and don't care for the lower stuff. (I'll probably houserule that if it is the case.)
At this point, the only thing they haven't talked about at great lengths is the Memoratium mechanic, which I'm really looking forward to hearing more about... (Sigh. It's only a week or so... be cool)
In the fluff department, Matthew also shared a few tidbits.
It also appears that:
Not all of the Sabbat have left for the middle-east, but most of them did. So, we can still have roaming Sabbat in the night, just not as many.
The Church of Caine is apparantly the Canite Heresy, and is thriving in these nights.
The Ravnos still blew up. ( 
I hope they just got sidelined until the surviving big guys can embrace a new Clan.)
The 2nd Inquisition were the ones that fucked up the Tremere and assaulted Vienna. Maybe they even managed to blow the fuck out of Saulot the Worm? In any case, the division in the Tremere is now very outspoken, and I'm guessing that the Tremere vs Carna vs Goratrix is the new normal.
Assamites are now always referred to as the Banu Haqim, and the term Assamite is going to be a derogatory.
The Followers of Set are now more normally known as the Ministry, and will be a lot more inclusive to the rest of the Clan's various faiths. I'm guessing the Clan of Faith is still a moniker that works?
The Ashirra is now struggling with the arrival of the Sabbat Crusaders and will be far more visible in the coming material. And a free for all between the Ashirra, the Sabbat and the elders who have joined with the rising progenitors? Maybe Enoch is trying to awake his childer?
London has fallen and there is not a single vampire left in the city after the inquisitors rolled through.
Apparently, Mithras/Monty saw them coming. And because he had apparantly been waiting for this exact time, he decided not to warn the rest of the city, except his own cult, allowing them to escape before proceeding to get destroyed in a epic battle royale against the Inquisition, but as Matthew said, there's a chance Mithras is not that easy to put down.