I had an idea back on HM long before GMC about an Architect of the Monolith who constructed a machine that corrupted the leylines and their raw life creating (and potentially reality creating) properties to sustain only vampiric life. But in the hands of someone else, sufficient nodes could reshape reality as they so desired.
On the Reach in the OD Academy, the Eye of Chiron was supposed to be part of a similar plot that was abandoned after Xanadu took over from Pompeii. The 'science' behind the artificial Crucible nest was it had arcane transformative powers.
On COFAB, this was meant to be something of a pieces race to reconstruct an altar whose owner could reshape reality. The earthquake was a consequence of someone trying to activate the machine as was the intention to do a thematic retcon to explain why COFAB only had Vampires and no other supernaturals (the person who triggered the machine had created a fissure in reality where no other supernatural could exist).
One Part 13 Ghosts Remake, One Part the Chase from Star Trek: Next Generation, One Part Mass Effect (in terms of the 'winning' faction of the GMC plot causing serious consequences including the possible end of the game), One Part Wrath of Khan/Genesis Device. Also, one part Star Trek Voyager: Year of Hell. I grew up watching a shit ton of Star Trek.
It was meant to explore the theme of hubris. I'm captivated by the biblical Tower of Babel. I liked my last iteration which was meant to force cooperation amongst unlikely factions and result in a situation where the game could have seriously ended if things went horribly wrong. But for various reasons, it did not go into fruition and I abandoned that narrative.
I am exploring in a pet project basically what would happen if human hubris resulted in the end of the world as we know it and the survivors trying to cope and possibly direct humanity's fate one way or another.