This is kind of a derail but I am really interested in using a system for my super game where I can fully automate all XP spending, which is one reason why I haven't settled on one yet. I've discovered that other than pure wealth economy systems like Dungeons & Dragons, nebulous money statistics (Resources from White Wolf, Fate, even Hero System) are a real pain in the ass. In very little time someone could go from broke to wealthiest person on the planet type stuff... it is an issue.
Back on topic:
I think with anime themed games the world itself has to be huge, and more expansive than just the player characters. I would think a world like Full Metal Alchemist would work, because the main characters are cool but hardly the most only alchemists on the planet. There are a lot of problems that can be used on the grid and it allows for a wide variety of game play as a setting.
Something like Knights of Sidonia... not so much.