After starting out with this on the PS4, I've been enjoying playing it on my new laptop. It's not a top-of-the-line gaming desktop with uber-powerful processing and graphics, but I can still run it on mostly High settings with a number of mods and pull around 30-35 FPS in the areas I've explored so far (not all of Boston, yet), and often around 50 or so indoors. That's good enough for me, especially at 1080p, if I can't run the thing on Ultra settings.
The nice thing is FNV runs exceptionally well at 60 FPS on Ultra settings, even with a bunch of texture mods installed. I'm not surprised given the fact it's older, but I have a feeling I'll get some solid performance out of Skyrim as well. I went on a little buying binge recently thanks to some sales.
Looking forward to the DLC content, too.