I tend to think that settings where equivalents to the viewpoint characters have to be extremely limited or else the whole setting collapses are maybe not the best choices for MU*.
Like, if someone had written a novel series from the viewpoints of what are in essence modern-day Antediluvians from VtM? I'd balk at making that game. If you let everybody play an Antediluvian the modern-day world will explode; and if everybody plays pawns of the Antediluvians, you're getting away from what the books are about, and a big chunk of your player base is, after all, mainly people who liked the books.