I suppose one avenue one might take is a step further with Touchstones.
Make every Social Merit (non-Vampiric in nature) that the character has have to have a connection with some mortal (that they probably feed off of from time to time).
So, my Resources 4? Connected to my financial advisor. My Allies (obvious). My Contacts (obvious). Etc. and have each of those Merits not just represent something abstract, but also be linked to ONE individual. And you can kill the individual for power--but you take a comparatively large hit in Humanity (gaining Blood Potency or whatever). Of course, some version of Sanctity of Merits might apply so you can rebuild that same Merit with someone else (or even replace it). Maybe I eat my financial advisor, but I then befriend his widow who is a medical examiner and acquire Contacts through her, etc.
However, all this demands a game where we put a lot more emphasis on the relationships vampires cultivate, to the point where it'd have to be at the very least one of two major themes (like it is in Vampyr).