Sort of yes? I've been toying with using the Storypath Ultra system to do a WoD-style game. I'm a big fan of the system and think it could be a good way to give a fresh coat of paint on things while keeping it familiar and comfortable.
MediaWiki requires a bit of tech savvy--setup, themes, maintenance. If you're looking for something that you can just kind of run with out of the box, you might consider wikidot instead. It doesn't have all the same bells and whistles, but it's free, easy to use, and serviceable.