I'm surprised more Vampire games aren't set in the Orthodox World and Eastern Europe broadly, considering our history and lore has influenced Anglo literary interpretation of vampires; Vlad the Impaler was an influence for Count Dracula, as an example.
I could easily see a game being centered around a human trafficking operation that sells pretty, nubile Slavic girls as blood dolls for vampires and brood mares for werewolves. I could similarly see generations of werewolves and mages fighting over long-abandoned commie blocks for the loci and hallows that were generated there during the period where they were occupied, and agreeing to some vile arrangement after a while to avoid further bloodshed. Maybe the Masquerade in certain cities has evaporated where local Princes captured dirty nukes during the fall of the Soviet Union, and have clung bitterly to them, requiring local and national officials to allow their vile kind to drink peasants dry and run the aforementioned human trafficking operations uninterrupted across international lines.
There is a lot of potential for horror in Eastern Europe.