@Bobotron
I may take you up on your offer. Vampire, is admittedly, my weak point. Mainly because I never really cared for the line per se. I enjoy playing in it. I just feel overwhelmed anytime I sit down and think about trying to put a sphere together.
Regarding the 2 or 3 cities. The more I think on it the more I'm fond of the idea. Strictly from the sense that it provides a Multi-Sphere game, but keeps each sphere isolated, save for a few cross over RPs. It also allows staff to really just run rampant in their city without fear of stepping on another sphere's plots and such. The only down side is the potential to separate the player base. As you mentioned if you have a heavy shifter sphere but a small vamp sphere then you run into issues.
I think it will be helped by rolling each game line out over time, like Haunted Memories did, rather than just dropping in the water with all ships sailing. That being said, I think this kind of game will appeal to players who want single sphere game attention, but access to multiple options with staff, they hopefully like and trust, running the ship.
Or maybe I'm just insane and not really getting any sane thoughts at the moment.