I haven't seen that show, yet, but I'll definitely see if Netflix has it now.
Part of the loose idea I had was to plot the way through the big die off after the cataclysmic /thing/ that causes the world to go nuts (I'm leaning towards good old, mundane fiscal collapse and people straight up turning on each other. Damn Ventrue borking Wallstreet. XD). I've been talking to some friends about using part of New York for the grid, and the debate is Manhatten island, Queens, Brooklyn, etc. I'm of a mind to start small and expand a grid as needed.
Plus, the idea of romping around in the Museum of Natural History gives me giddy little flashbacks to Parasite Eve.