I did a read-though of the wiki content thus far, including the news files. This looks like it will be an excellent and well thought out setting, pending Werewolf additions once the new core is released. I have my fingers crossed that they (they being Onyx, not you folks) don't wreck WtF overly much.
The neighborhood system is very interesting. Given the soft opening (or whatever else you'd like to call it) and initial player disorganization, do you intend to uphold the "3 players to claim a neighborhood" or will you allow smaller units to pitch ideas for neighborhoods without owning them?
I noticed in a few of the grid-square descriptions, notably MW1 and MW2, that there is a Pan-Asian, Eastern European, and Middle Eastern component. That's a pretty huge and diverse ethnic and religious spread. Would my assumption that you intend the neighborhood system to allow for some narrow focus ethnic communities (Chinatown, Little Albania, etc.) be correct or did you want those areas to be a general ethnic mishmash?
"The Mob" seems to be a general clumping of organized crime that isn't Triad or Mexican Cartel. Do you intend to flesh out some sort of overall, loose structure that portrays how all the various mobs (Russian, Irish, Amish, Albanian, etc.) work together under this framework? Will players take a general Status-Mob merit or will they focus on their Status-Amish Mafia specification?
How involved in the God-Machine happenings will players from the non-Demon spheres be? How rare will knowledge of its existence be for the general supernatural population?
Great start guys. Looking forward to playing there.