The Protectorate-level story seems really, really interesting. Especially if you allow 2e Werewolf to add in your sheet's Wolf-Blooded. You could have an entire plethora of related PCs to play in the skin of, and to portray. And that can lead to a very unique experience.
Right now it's a shrieking COI discussion when someone plays related characters. But 2e kind of turns that on it's ear. If you could have 3 or 4 related characters, working with 3 or 4 other people, the volume of stories has a very real possibility of becoming super interesting, because while you might be playing your Retainer, or your Wolf-Blooded, or your Werewolf, or your Totem, you're still focusing on your Territory, and how it relates to those in it, and those bordering it.
And the instant travel part of 2e ties it all together in this enormously interesting way. Can you imagine a game of that size, and then change the scope to add a Shadow of the same dimension? It'd be enormous! Just, enormous! You could have all of Mt. Rainer to your group, along with all the towns around it.
Now, you do have to take a breath and think, that's really sandboxed. So, how can you carrot people into playing in one another's territory? Otherwise it'd be very lonely after a time. Your barp is going to suffer, and sometimes you really do just want to barp. So there has to be a mechanism or a benefit to going to other people's towns and rolling down other people's highways to increase the world building. Maybe the bigger cities aren't Territory and everyone can use them, and certain types of resources only come from there? I don't know. I'm neither intelligent enough to come up with that carrot or visionary.
But a huge Protectorate would be amazing with that layered sheet in 2e Werewolf.