To answer bullet points first:
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Can/should (re: Ghoul/Vamp)? I generally like to frame this as a matter of equal opportunity looking from Cgen forward. Anyone can make a character that could star in big stories. Some people may choose not to (L&L Firan/Arx version: some people just wanna be crafters, etc), and the conventions on what a 'main' char is would probably vary a lot by genre. Now, feasible? I'd actually hope so, but it goes to #2.
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It can't be achieved without making OOC rules about it. You probably want to make OOC rules about it.
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I had a larger (and very @Thenomain sounding) breakdown about this based on player type, but coming up with it I realized that it's mostly incidental. Aside from players who are really thinking about a narrative arc in a formal way (ie, players with writing/acting backgrounds) most people aren't thinking about it explicitly. But the goals they like (defeating big bads, achieving plot milestones, drawing in a social circle, revealing elements of the setting) all happen either exclusively or much more intensely 'inside' the GM spotlight.
Beyond that, I actually wanted to comment on one thing I saw in that thread though avoided it because I figured @Apos would just declare me the devil again and it would kinda derail the point. But it got brought up there, and while this is a more extreme version, it's still essentially the same question:
@cobaltasaurus said in Arx thread 2: Electric Boogaloo:
Do you want me to retire my character into the sunset because he did A Thing in the past season?
I'd argue that games actually probably need to figure out mechanisms to say 'yes' to this question, at least sometimes. To be clear, I'm not criticizing Cobalt here as the game had no such rule (and moreover it sounds like she wasn't the focus anyway). But seeing the same player names associated with big events over and over again absolutely can have a negative impact on the newer players. It's the old dino question in a different form.
Now, I'd also point out that obviously you shouldn't just tell them to literally retire into the sunset, because then the player response will be 'OK well, I guess I quit?', whether to take a new alt or permanently. But there could certainly be something to using, say, narrative currencies or the like to buy into big events, to push to the forefront of those events, whereby you'd have to wait at least a while before you could be the big damn hero again.
In some thread long ago I said something about plot DKP - this is basically that discussion come around again.