In no order but alphabetical. Omitting channels already mentioned as of time of writing just to stoke the mystery of which ones I watch. I also left out the twenty or so ASMR channels I watch.
Bowlingotter: A pair of married Let's Players with terrific chemistry (I mean, you'd hope so, right?) and a dorky earnestness you don't get from other channels who're trying so hard to be above it all. I knew I was on board forever when Lissy Sandwich broke into open tears at the end of To The Moon.
CinemaWins: Because too much of the internet thinks film criticism is about finding flaws to establish your mental superiority over the people making movies. Here is a channel about celebrating what makes movies a good time, and while some of it is a stretch, this guy knows the language of film.
Hbomberguy: A feminist and leftist (or possibly liberal, I forget which) who invites you to laugh at stupid people being stupid by citing evidence and reason to explain why they're stupid. Maybe that sounds mean, but he picks truly worthy targets like MRAs, Flat Earthers, and Nazis, so I think it's morally justified.
Jim Sterling: Video game punditry, staunch anti-capitalism, pro-LGBTQ support, and the kind of bizarre humor you can only get from the English. Can't recommend highly enough.
Philosophy Tube: One of the bravest, smartest people on the internet, explaining the mechanics behind the arguments and actions people taking in a relentlessly self-critical way while channeling seemingly endless creativity into the characters and scenarios of his sketches. Olly's improved a lot in last few years after escaping an abusive relationship he's pretty open about discussing, which... the man is a hero to me.
Thought Slime: After so long on the internet listening to edgelords babble about anarchy as a vessel for their thoughtless self-adulation, I had no idea anarchy is a philosophy with a coherent ethos and a serious, achievable set of goals. This channel is run by a man doing his best to try to convince people to care that they exist in a system designed to treat us all as prey and to set us against one another to sacrifice our peers to the greed of those who oppress us all rather than resist as a unified mass. He makes it sound funnier than I do, though.
Tofupupper: In the words of Tofu-Chan himself, "The other night I had a dream where you subscribed to my channel and then I licked your face. Please make it come true." Absurd, abstract comedy built around a handsome goodboi who is apparently also a motivational speaker because why wouldn't he be? Look at his face and tell me you don't feel motivated. Do it. I dare you.