MU*s have had their death knell toll. Why play with other boring, creepy, annoying, etc. people by text, when you can satisfy that itch with single-player awesomeness that have this shiny new thing called graphics?
Lords & Ladies your jam? Lakeburg Legacies is a city management sim, where you also have to match the townsfolk and local nobles to get romance to bloom and make babies who will grow up and help the kingdom thrive. (On a more serious note: There's a bit of a eugenics feel here that may put some people off, as you're wanting to match people with certain traits to make babies that have even better versions of those traits so your kingdom can prosper.) As PartyElite put it in his Youtube review of strategy games at this E3, "Is this a new hybrid genre of city builder and dating sim?"
What's that? You prefer your Lords & Ladies IN SPAAAACE (because everything is better IN SPAAACE)? Well, have no fear, for someone has finally, FINALLY made the Crusader Kings IN SPAAACE that we have all been hungering for in Alliance of the Sacred Suns. You are a Space Emperor of Space and you must manage Space Houses with their Space Nobles in a Feudal Society in Space. what more needs to be said?
Maybe you're done with the L&L and you're looking more for some hard sci-fi action, a la Battlestar Galactica or the Expanse. Well, you better Starbuckle up, because Falling Frontier is a space-based RTS game with all of that delicious hard sci-fi flavor (other than the superluminal stuff). Early Access was supposed to be this month, but they've delayed it to later this year.
What? That's not hard enough sci-fi for you? You want something based around earth and set in the near-future? Meet the XCom I personally wanted - Terra Invicta. Play as one of Earth's countries as we discover aliens on the edge of the solar system. Fight the aliens or other countries or both!
Maybe you're a fan of Civilization 6, but always thought it was weird that Cleopatra of Egypt was going to war with Theodore Roosevelt of America in 200 AD. Well, someone finally fixed that with Humankind (probably the game I most excited about). Move through seven eras, picking a new culture for your faction to represent in six of them, slowly building a combination of traits and bonuses that stick with you through the ages. It's being made by the same guys that made Endless Space I & II and Endless Legend, so, if you were a fan of those, then...well, you probably already know about this game.
Wow! That's a whole lot of simulation and strategy games! Yes, that's because that's what I like to play. Did something non sim-y or strategerie oriented get shown at E3 that you want to discuss? Shout your hype here.