I still think CthulhuTech would make an amazing Mu*.
Despite the books being overpriced, the setting isn't based on "what kind of special you are", like WoD, but more "which scale of the CthulhuTech stuff are you involved in?"
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There's an entire setting for a Band of Brothers style military campaign, which is currently a losing battle, where humans use soldiers, tanks, and MECHA (including mecha-altered Lovecraftian beasts called Engels) to fight any number of cosmic entity armies, like the Mi-Go, attacking Earth.
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Then the scale gets smaller. You have the city life, which includes everything from hackers, to private investigators, to prostitutes and police, living within society centers which are constantly at risk of infiltration by the cult of Nyarlothotep. You could effectively film noir this setting, like Sin City, to tell any number of stories, or have characters be drafted/enlisted into #1, the war campaign.
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Even smaller in scale are the fringe cults (hunted by #2) who use stolen texts of Nyarlothotep to bond with a monster. They become tagers, which are basically overpowered humans who shift into fleshy monsters, and they are constantly at risk of losing themselves to the alien psychology. However, they are actually good guys who risk being hunted and murdered while they fight a shadow war against the ACTUAL cults who are attacking both #1 and #2. The mortality rate for Tagers is so high, you could probably rotate who has an opportunity to play a tager through your player base, avoiding "slots" or "applications" in favor of hard no-consent rules and high risk combat.