I see the fundamental question of science fiction to be what would humans do or be like given a situation X? That could be technology (replicants or stacks), culture (the Culture or stand alone complex), bizarrely specific situations (Spice) etc.
Cyberpsychosis is a balancing mechanism, but also a way to represent something valuable to roleplaying: a hook, a visceral feel for things a character may go through or experience the effects of. Humanity/Paths in Vampire had a lot of focus for this experience for a while.
I've mentioned is often, but the Madness Meters in Unknown Armies offer that sort of hook. There is more than one, so you can choose many issues to address like
- becoming very different in perspective due to info input from sensors or being invulnerable to what used to hurt,
- entering a psychological feedback ego loop that causes psychotic disregard for life, or people, or the idea of individual bodies etc
- addiction to new stimulus or possibilities
- internal alienation from others
- external appearance or capacity based exclusion/treatment (you look weird, you look built for a specific purpose, people like you are expendable)
Etc. You can also just say that any thematic difficulty CAN have a staged disadvantage you choose to have your character go through. However, like violence and addiction you need to set up how society at large is handling it so the players know what to expect from the world.