It's also somewhat possible to hybridize the two.
I mean, as it is, a lot of people play WoD as 'superheroes with fangs or fur'.
Pretty sure that indicates an audience for something that might be along the lines of a superheroes game, but with supernatural overtones and supernatural sources of powers. You could make a few basic templates of a sort if people want a simple pick-up-and-go for basic creature 'species' of a sort (generic vampire, generic animal shifter, etc.), and allow for more freeform things as well for those willing to crunch it.
As it is, there are characters like John Constantine and Doctor Strange in comics that have a much more mystical/supernatural bent. A society in which these types are 'out of the coffin' could be pretty damn creative and fun, I'd think.
I will admit, it was one of the fun aspects of Darkmetal: supers were known. Hunted/illegal, but known. If stripping out some of the edgelord trenchcoats and katanas and grimdark and cyberpunk from that sort of arrangement? I would think that could be a heck of a lot of fun. (And even some of the edgelord grimdark could be a thing in certain parts of town, etc.) You could create a fairly interesting world out of that pretty easily -- like licenses for being a thing, etc. in a similar fashion to Nigthwatch/Daywatch/etc. as well, and so on.