How about this for what we're looking for (specifics-free to give us options):
- Geographically plausible - if possible a single city-setting (maybe a nexus/cultural crossroads). We really don't want to splinter the playerbase into X different nations separated by hundreds of miles between them.
- Liberated women. We want strong female characters to be a possibility.
- Politics should be a thing. Different tribes? Houses? Room to grow for PCs.
- Dangerous but lawful. There should be threats, physical and otherwise, but non-physical characters will need to have roles to play.
Some initial questions:
- Vampires versus Werewolves or collaborative? Are PCs on the same side, antagonistic, cold war?
- Is there a Masquerade or are monsters' existence commonly accepted outside superstition? Do they walk openly as what they are?