Everything that @Arkandel said. All of it. Especially the 'access to plot' bit. Far too often Plot goes to either a) the person who is on all the time and able to do all the things or b) the person who has the right connections and hears the right information. This is not good or healthy. You want the newbie who doesn't know anyone to be able to get involved easily. You also want the person who only has a few nights a week to devote to RP to be able to have meaningful interactions.
As to the small group stuff. Meh. I've seen coteries and packs work fine- but players may need a little assistance finding one. That means you've gotta be pushing players towards each other, and I don't see that happening on WoD games. Ever. People just sit with their gazillion alts in the OOC rooms and wait for PRPs. I don't think that culture works and I don't think there will be a successful WoD game unless it tackles that culture.