Vault Hunters:
Taking place on Pandora, players are all visiting vault hunters, looking to make their mark and get their fortune.
They soon find out it is a hellish nightmare world where New You(I know New You isn't canon, but I think the setting works better where it is) technology means nobody actually dies, and eventually devolve into savagery.
I think the WoD system might work for this, or some other one that's better at run n gun PrPs with a similar system to the Vampire humanity scores being used. You might die, but you're re-digitized at a nearby station, as are all those mooks you've killed. Fortunately, once someone loses all their humanity, their ability to learn and remember doesn't go past a trip through New You. If a PC loses all their humanity, the effectively become static NPCs.