I just don't really see what the Shadowrun setting brings to the table for a superhero game, especially one set in Marvel/DC canon. Shadowrun is cynical, dystopic, and generally speaking pretty low-powered and street level in focus.
Toss supers into the mix and all of that stops making sense. Why would the Justice League/Avengers even allow some of the biggest events of Shadowrun to occur without intervention, like the rise of the dragons and megacorps? Wouldn't Doctor Fate/Doctor Strange be working to stop or reverse goblinization as soon as it started?
Completely handwaving all of that and just splicing the setting together, what place would your typical shadowrunner have in a world where even as a team they are frankly outclassed by even a single lowest tier super? Why would you play as anything else?
The scales and themes are just so mismatched to me that I have a hard time seeing what the appeal is, as opposed to using like a blend of the Legion of Superheroes and Marvel 2099 if you want a far-future high tech setting?